9) MULTIPRED: a computational system for prediction of promiscuous HLA binding.
Zhang GL, Khan AM, Srinivasan KN, August JT, Brusic V.
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W172-9.
PUBMED PMID: 15980449
Out link: Full-text
Impact Factor Year 2009: 7.479
No. of Citations: 70 (total): 51 (non-self) & 19 (self)
ABSTRACT :
MULTIPRED is a web-based computational system for the prediction of peptide binding to multiple molecules (proteins) belonging to human leukocyte antigens (HLA) class I A2, A3 and class II DR supertypes. It uses hidden Markov models and artificial neural network methods as predictive engines. A novel data representation method enables MULTIPRED to predict peptides that promiscuously bind multiple HLA alleles within one HLA supertype. Extensive testing was performed for validation of the prediction models. Testing results show that MULTIPRED is both sensitive and specific and it has good predictive ability (area under the receiver operating characteristic curve A(ROC) > 0.80). MULTIPRED can be used for the mapping of promiscuous T-cell epitopes as well as the regions of high concentration of these targets--termed T-cell epitope hotspots. MULTIPRED is available at http://antigen.i2r.a-star.edu.sg/multipred/.
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