3) ANTIMIC: a database of antimicrobial sequences.

Brahmachary M, Krishnan SP, Koh JL, Khan AM, Seah SH, Tan TW, Brusic V, Bajic VB.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D586-9.
PUBMED PMID: 14681487
Out link: Full-text
Impact Factor Year 2009: 7.479
No. of Citations: 86 (t0tal): 84 (non-self) & 2 (self)

ABSTRACT :

Antimicrobial peptides (AMPs) are important components of the innate immune system of many species. These peptides are found in eukaryotes, including mammals, amphibians, insects and plants, as well as in prokaryotes. Other than having pathogen-lytic properties, these peptides have other activities like antitumor activity, mitogen activity, or they may act as signaling molecules. Their short length, fast and efficient action against microbes and low toxicity to mammals have made them potential candidates as peptide drugs. In many cases they are effective against pathogens that are resistant to conventional antibiotics. They can serve as natural templates for the design of novel antimicrobial drugs. Although there are vast amounts of data on natural AMPs, they are not available through one central resource. We have developed a comprehensive database (ANTIMIC, http://research.i2r. a-star.edu.sg/Templar/DB/ANTIMIC/) of known and putative AMPs, which contains approximately 1700 of these peptides. The database is integrated with tools to facilitate efficient extraction of data and their analysis at molecular level, as well as search for new AMPs. These tools include BLAST, PDB structure viewer and the Antimic profile module.

This article has been cited by other articles:

1) Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P. Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions. Biochemistry. 2004 Jul 6;43(26):8391-409. PMID: 15222751

2) Markossian KA, Zamyatnin AA, Kurganov BI. Antibacterial proline-rich oligopeptides and their target proteins. Biochemistry (Mosc). 2004 Oct;69(10):1082-91. Review.
PMID: 15527407

3) Chinese Journal of Antibiotics. 2004, 29(5):272-274. http://engine.cqvip.com/content/R/91478X/2004/029/005/YY18_R18_9711558.pdf

4) Koh JLY, Krishnan SPT, Seah SH, Tan PT, Khan AM, Lee ML, Brusic V. BioWare: A framework for bioinformatics data retrieval, annotation and publishing. 27th Annual International ACM SIGIR Conference on Research and Development in IR. Sheffield, UK, July 29, 2004. http://lair.indiana.edu/sigirbio/final/koh.pdf

5) Araki, M, Katayama, T, Matsuura, Y, Kanehisa, M. KEGG PEPTIDE: A Database for Peptide Structures. http://www.jsbi.org/journal/IBSB04/IBSB04P038.pdf

6) Zhou, Y.-W., Yin, Y.-B., Tu, Z.-G., Chen, H., Zhang, X.-M., Meng, J.-P., Zhu, D. Study on antibacterial activity and mechanism of housefly antimicrobial peptide. Chinese Journal of Antibiotics. 2004, 29 (5), pp. 272-274

7) WORLD NOTES ON ANTIBIOTICS. 2005 Vol.26 No.5 P.205-208. http://www.wanfangdata.com.cn/qikan/periodical.articles/gwyykssfc/gwyy2005/0505/050503.htm

8) Tossi A. Host defense peptides: roles and applications. Curr Protein Pept Sci. 2005 Feb;6(1):1-3. PMID: 15638764

9) Beisswenger C, Bals R. Functions of antimicrobial peptides in host defense and immunity. Curr Protein Pept Sci. 2005 Jun;6(3):255-64. Review. PMID: 15974951

10) Khandelia H, Kaznessis YN. Molecular dynamics simulations of the helical antimicrobial peptide ovispirin-1 in a zwitterionic dodecylphosphocholine micelle: insights into host-cell toxicity. J Phys Chem B. 2005 Jul 7;109(26):12990-6. PMID: 16852612

11) Rausch JM, Marks JR, Wimley WC. Rational combinatorial design of pore-forming beta-sheet peptides. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10511-5. Epub 2005 Jul 14. PMID: 16020534

12) De Smet K, Contreras R. Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett. 2005 Sep;27(18):1337-47. Review. PMID: 16215847

13) Simonsen SM, Sando L, Ireland DC, Colgrave ML, Bharathi R, Göransson U, Craik DJ.
A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Plant Cell. 2005 Nov;17(11):3176-89. Epub 2005 Sep 30. PMID: 16199617

14) Zamyatnin AA, Borchikov AS, Vladimirov MG, Voronina OL. The EROP-Moscow oligopeptide database. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D261-6. PMID: 16381860

15) Wang, GS. Structural biology of antimicrobial peptides by NMR spectroscopy.
Current Organic Chemistry 2006, Mar; 10(5):569-581.

16) Li X, Li Y, Han H, Miller DW, Wang G. Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J Am Chem Soc. 2006 May 3;128(17):5776-85. PMID: 16637646

17) Khandelia H, Kaznessis YN. Molecular dynamics investigation of the influence of anionic and zwitterionic interfaces on antimicrobial peptides' structure: implications for peptide toxicity and activity. Peptides. 2006 Jun;27(6):1192-200. Epub 2005 Dec 1. PMID: 16325306

18) Giacometti A, Cirioni O, Ghiselli R, Mocchegiani F, Orlando F, Silvestri C, Bozzi A, Di Giulio A, Luzi C, Mangoni ML, Barra D, Saba V, Scalise G, Rinaldi AC. Interaction of antimicrobial peptide temporin L with lipopolysaccharide in vitro and in experimental rat models of septic shock caused by gram-negative bacteria. Antimicrob Agents Chemother. 2006 Jul;50(7):2478-86. PMID: 16801429

19) Nagarajan V, Kaushik N, Murali B, Zhang C, Lakhera S, Elasri MO, Deng Y. A Fourier Transformation based Method to Mine Peptide Space for Antimicrobial Activity.
BMC Bioinformatics. 2006 Sep 26;7 Suppl 2:S2 [Epub ahead of print] PMID: 17118141.

20) Li X, Li Y, Peterkofsky A, Wang G. NMR studies of aurein 1.2 analogs. Biochim Biophys Acta. 2006 Sep;1758(9):1203-14. Epub 2006 Apr 7. PMID: 16716252

21) Brahmachary M, Schönbach C, Yang L, Huang E, Tan SL, Chowdhary R, Krishnan SP, Lin CY, Hume DA, Kai C, Kawai J, Carninci P, Hayashizaki Y, Bajic VB. Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. BMC Bioinformatics. 2006 Dec 18;7 Suppl 5:S8. PMID: 17254313

22) Gueguen Y, Garnier J, Robert L, Lefranc MP, Mougenot I, de Lorgeril J, Janech M, Gross PS, Warr GW, Cuthbertson B, Barracco MA, Bulet P, Aumelas A, Yang Y, Bo D, Xiang J, Tassanakajon A, Piquemal D, Bachère E. PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature. Dev Comp Immunol. 2006;30(3):283-8. PMID: 15963564

23) Bals R, Hiemstra PS. Antimicrobial peptides in COPD--basic biology and therapeutic applications. Curr Drug Targets. 2006 Jun; 7(6):743-50. PMID: 16787176

24) GUO, G, WU, JW. Isolation of peptides from Musca domestica larvae secretion and study on their antibacterial effect. INTERNATIONAL JOURNAL OF MEDICAL PARASITIC DISEASES. 2006 Vol.33 No.1 P.6-9.

25) Seebah S, Suresh A, Zhuo S, Choong YH, Chua H, Chuon D, Beuerman R, Verma C. Defensins knowledgebase: a manually curated database and information source focused on the defensins family of antimicrobial peptides. Nucleic Acids Res. 2007 Jan;35(Database issue):D265-8. Epub 2006 Nov 7. PMID: 17090586

26) Langham, A.A., Kaznessis, Y.N. Effects of mutations on the C-terminus of protegrin-1: A molecular dynamics simulation study. Molecular Simulation. 2006, 32 (3-4), pp. 193-201

27) van Baarlen P, van Belkum A, Summerbell RC, Crous PW, Thomma BP. Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps? FEMS Microbiol Rev. 2007 Apr;31(3):239-77. Epub 2007 Feb 26. Review. PMID: 17326816

28) Wang G. Tool developments for structure-function studies of host defense peptides. Protein Pept Lett. 2007;14(1):57-69. Review. PMID: 17266652

29) Jerala R. Synthetic lipopeptides: a novel class of anti-infectives.
Expert Opin Investig Drugs. 2007 Aug;16(8):1159-69. Review. PMID: 17685866

30) Rausch JM, Marks JR, Rathinakumar R, Wimley WC. Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry. 2007 Oct 30;46(43):12124-39. Epub 2007 Oct 6. PMID: 17918962

31) Lata S, Sharma BK, Raghava GP. Analysis and prediction of antibacterial peptides.
BMC Bioinformatics. 2007 Jul 23;8:263. PMID: 17645800

32) Altincicek B, Vilcinskas A. Analysis of the immune-inducible transcriptome from microbial stress resistant, rat-tailed maggots of the drone fly Eristalis tenax. BMC Genomics. 2007 Sep 17;8:326. PMID: 17875201

33) Fjell CD, Hancock RE, Cherkasov A. AMPer: a database and an automated discovery tool for antimicrobial peptides. Bioinformatics. 2007 May 1;23(9):1148-55. Epub 2007 Mar 6. PMID: 17341497

34) TUO, XY, CHAI, JK. Research Progress in Gene Engineering of Antimicrobial Peptides. LETTERS IN BIOTECHNOLOGY. 2007 Vol.18 No.2 P.298-300. http://www.wanfangdata.com.cn/qikan/periodical.articles/swjstx/swjs2007/0702/070237.htm

35) Hammami R, Zouhir A, Ben Hamida J, Fliss I. BACTIBASE: a new web-accessible database for bacteriocin characterization. BMC Microbiol. 2007 Oct 17; 7:89. PMID: 17941971

36) Rausch JM, Marks JR, Rathinakumar R, Wimley WC. Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry. 2007 Oct 30;46(43):12124-39. Epub 2007 Oct 6.PMID: 17918962

37) Mookherjee N, Rehaume LM, Hancock RE. Cathelicidins and functional analogues as antisepsis molecules. Expert Opin Ther Targets. 2007 Aug;11(8):993-1004. PMID: 17665972

38) Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD. The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. Insect Biochem Mol Biol. 2008 Feb; 38(2):201-12. Epub 2007 Nov 17. PMID: 18207081

39) Stensvåg K, Haug T, Sperstad SV, Rekdal O, Indrevoll B, Styrvold OB. Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus. Dev Comp Immunol. 2008;32(3):275-85. Epub 2007 Jul 2. PMID: 17658600

40) Minkiewicz, P., Dziuba, J., Darewicz, M., Iwaniak, A., Dziuba, M., Nałȩcz, D. Food peptidomics. Food Technology and Biotechnology. 2008, 46 (1), pp. 1-10

41) Park TJ, Kim JS, Choi SS, Kim Y. Cloning, expression, isotope labeling, purification, and characterization of bovine antimicrobial peptide, lactophoricin in Escherichia coli. Protein Expr Purif. 2009 May;65(1):23-9. Epub 2008 Dec 24. PMID: 19130889

42) Cheng X, Liu G, Ye G, Wang H, Shen X, Wu K, Xie J, Altosaar I. Screening and cloning of antimicrobial DNA sequences using a vital staining method. Gene. 2009 Feb 1;430(1-2):132-9. Epub 2008 Nov 5. PMID: 19027836

43) PhytAMP: a database dedicated to antimicrobial plant peptides. Hammami R, Ben Hamida J, Vergoten G, Fliss I. Nucleic Acids Res. 2009 Jan;37(Database issue):D963-8. Epub 2008 Oct 4.
PMID: 18836196 [PubMed - indexed for MEDLINE]

44) Wang G, Li X, Wang Z. APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res. 2009 Jan;37(Database issue):D933-7. Epub 2008 Oct 28.
PMID: 18957441

45) Li Y, Chen Z. RAPD: a database of recombinantly-produced antimicrobial peptides.
FEMS Microbiol Lett. 2008 Dec;289(2):126-9. PMID: 19054102

46) Soltani, S., Keymanesh, K., Sardari, S. Evaluation of structural features of membrane acting antifungal peptides by Artificial Neural Network. Journal of Biological Sciences, 2008, 8 (5), pp. 834-845

47) Giuliani A, Pirri G, Bozzi A, Di Giulio A, Aschi M, Rinaldi AC. Antimicrobial peptides: natural templates for synthetic membrane-active compounds. Cell Mol Life Sci. 2008 Aug;65(16):2450-60. Review. PMID: 18661101

48) Wase, N.V., Wright, P.C. Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery. Expert Opinion on Drug Discovery, 2008, 3 (8), pp. 903-929.

49)
Minkiewicz P, Dziuba J, Iwaniak A, Dziuba M, Darewicz M. BIOPEP database and other programs for processing bioactive peptide sequences. J AOAC Int. 2008 Jul-Aug;91(4):965-80. Review. PMID: 18727559

50) Steinstraesser L, Koehler T, Jacobsen F, Daigeler A, Goertz O, Langer S, Kesting M, Steinau H, Eriksson E, Hirsch T. Host defense peptides in wound healing. Mol Med. 2008 Jul-Aug;14(7-8):528-37. Review. PMID: 18385817

51) Diamond G, Beckloff N, Weinberg A, Kisich KO. The roles of antimicrobial peptides in innate host defense. Curr Pharm Des. 2009;15(21):2377-92. PMID: 19601838

52) K Stensvåg, T Haug, C LI, OB Styrvold, H, Novel polypeptides, 2008. freepatentsonline.com

53) D der Veterinärmedizin, K Reithmayer - diss.fu-berlin.de, Studies on the antimicrobial defence of human hair follicle epithelium. Thesis, 2008, Berlin.

54) Ahamed Hassain Malim, N.H. and Zainol, Zurinahni (2007) Extraction Of Defensin Antimicrobial Peptide From SWISS-PROT Database Using Extended Boyer-More Algorithm. In: International Conference On Electrical Engineering And Informatics (ICEEI 2007), 17-19 June 2007, Institut Teknologi Bandung, Indonesia. http://eprints.usm.my/9430/

55) van Baarlen P, van Belkum A, Summerbell RC, Crous PW, Thomma BP. Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps? FEMS Microbiol Rev. 2007 Apr;31(3):239-77. Epub 2007 Feb 26. Review. PMID: 17326816

56) Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?
Steinstraesser L, Kraneburg UM, Hirsch T, Kesting M, Steinau HU, Jacobsen F, Al-Benna S.
Int J Mol Sci. 2009 Sep 9;10(9):3951-70.
PMID: 19865528

57) 天然抗菌肽的来源及分类
nykxw.com [PDF]梁永利 - 安徽农业科学, 2006 - nykxw.com
http://www.nykxw.com/loadimg/200610137715909.pdf

58) 家蝇幼虫分泌物抗菌组分的抗菌效果观察及筛选
国果, 吴建伟 - 国际医学寄生虫病杂志, 2006 - cqvip.com
http://www.cqvip.com/qk/94748a/2006001/21246161.html

59) Antimicrobial peptides of the oral cavity.
Gorr SU.
Periodontol 2000. 2009;51:152-80. Review. No abstract available.
PMID: 19878474

60) CAMP: a useful resource for research on antimicrobial peptides.
Thomas S, Karnik S, Barai RS, Jayaraman VK, Idicula-Thomas S.
Nucleic Acids Res. 2010 Jan;38(Database issue):D774-80. Epub 2009 Nov 18.
PMID: 19923233

61) Development of agents that modulate protein-protein interactions in membranes.
Zhao TX, Martinko AJ, Le VH, Zhao J, Yin H.
Curr Pharm Des. 2010;16(9):1055-62. Review.
PMID: 20030619

62) 中国林蛙 (Rana chensinensis) 蛙皮抗菌肽的制备及抗菌作用研究
刘红玉, 崔洪斌 - 中国食品卫生杂志, 2007 - cqvip.com
http://www.cqvip.com/qk/81177x/200703/24550657.html

63) 家蝇抗菌肽的免疫诱导及抗菌活性研究
周义文, 姬尚义, 申萍, 涂植光, 尹一兵, 陈辉, 孟江萍 … - 临床检验杂志, 2008 - cqvip.com
http://www.cqvip.com/qk/91229x/2008001/26381547.html

64) 抗生素多肽
李小永, 于洪涛 - 国外医药: 抗生素分册, 2005 - cqvip.com
http://www.cqvip.com/qk/95550x/2005005/20168789.html

65) 两亲 α-螺旋抗菌肽的分子设计研究现状与进展
李趣欢, 张文军 - 中国新药杂志, 2005 - cqvip.com
http://www.cqvip.com/qk/97417a/2005009/20232206.html

66) BACTIBASE second release: a database and tool platform for bacteriocin characterization.
Hammami R, Zouhir A, Le Lay C, Ben Hamida J, Fliss I.
BMC Microbiol. 2010 Jan 27;10:22.
PMID: 20105292

67) AntiBP2: improved version of antibacterial peptide prediction.
Lata S, Mishra NK, Raghava GP.
BMC Bioinformatics. 2010 Jan 18;11 Suppl 1:S19.
PMID: 20122190

68) 中国林蛙皮抗菌肽提取条件的优化研究
金莉莉, 丁忠福, 王秋雨 - 食品科学, 2008 - cqvip.com
http://www.cqvip.com/qk/95574x/2008010/28687691.html

69) 草鱼肠道抗菌肽的提取及体外抑菌效果初步研究
苏建明, 雷红宇, 黄平, 肖调义 - 湖南农业大学学报: 自然科学版, 2009 - cqvip.com
http://www.cqvip.com/qk/93062a/2009002/30413743.html

70) 抗菌肽数据库简介
马宝林, 李夏兰, 宋宝珍 - 生物学通报, 2007 - cqvip.com
http://www.cqvip.com/qk/90078x/200705/24389116.html

71) Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae.
Smith VJ, Desbois AP, Dyrynda EA.
Mar Drugs. 2010 Apr 14;8(4):1213-62.
PMID: 20479976

72) Toward Promoter Analysis of Antimicrobial Peptide Genes
MQ Zhang, TW Tan - nus.edu.sg
http://www.nus.edu.sg/nurop/2009/FoS/14th%20NUROP%20Congress_FoS/Life%20Sciences/Biochemistry/Zhang%20Mengqi_U052053U.pdf

73) Bioinformatics-coupled molecular approaches for unravelling potential antimicrobial peptides coding genes in brazilian native and crop plant species.
Pestana-Calsa MC, Ribeiro IL, Calsa T Jr.
Curr Protein Pept Sci. 2010 May 1;11(3):199-209.
PMID: 20088767

74) Antimicrobial Peptide immunity protects human nasal and auricular cartilage against infection.
Warnke PH, Russo PA, Hopfenziz M, Kurz B, Becker ST, Sherry E, Springer I, Sivananthan S.
J Craniofac Surg. 2010 Jan;21(1):198-201.
PMID: 20098184

75) Current trends in antimicrobial agent research: chemo- and bioinformatics approaches.
Hammami R, Fliss I.
Drug Discov Today. 2010 Jul;15(13-14):540-6. Epub 2010 May 26.
PMID: 20546918

76) Z HAILEI
Prediction of novel biochemical class disease related proteins and microRNAs by machine learning approach
PhD Thesis, 2009, National University of Singapore

77) FF Dermatology
STUDIES ON THE ROLE OF THE CATHELICIDIN PEPTIDE LL-37 IN EPITHELIAL BIOLOGY
PhD Thesis 2010
Karolinska Institutet, Stockholm, Sweden

78) Antimicrobial activity of short, synthetic cationic lipopeptides.
Laverty G, McLaughlin M, Shaw C, Gorman SP, Gilmore BF.
Chem Biol Drug Des. 2010 Jun;75(6):563-9. Epub 2010 Mar 30.
PMID: 20374251

79) Péptidos antimicrobianos
GA Téllez, JC Castaño - Infectio, 2010 - revistainfectio.org
Infectio. 2010; 14(1): 55-67

80) Defensine des Pferdes
O Bruhn - tierzucht.uni-kiel.de

81) 半翅目蝽科昆虫小皱蝽 (Cyclopelta parva Distant) 抗菌物质的诱导, 提取及活性检测
杨泽宏, 杨星勇, 何清君 - 四川大学学报: 自然科学版, 2007 - cqvip.com
http://www.cqvip.com/qk/93239x/2007005/25793846.html

82) 植物基因工程在桑树品种改良中的应用进展
林天宝, 吕志强, 胡张华, 朱燕 - 蚕桑通报, 2009 - cqvip.com
http://www.cqvip.com/qk/91813x/2009001/29775621.html

83) Y Hsiao
Analysis of Antimicrobial Peptide Database and Molecular Dynamics Simulation of Antimicrobial Peptide, indolicidin in a water-membrane environment
PhD Thesis - 2009 - thesis.lib.ncu.edu.tw

84) MM LÓPEZ
Obtención de moléculas lineales de AS-48 que conserven la estructura tridimensional y la actividad biológica de la molécula nativa
PhD Thesis, 2009, Universidad De Granada
http://hera.ugr.es/tesisugr/17713043.pdf

85) Actualidad Científica
C Científicas - biologia.puce.edu.ec
http://www.biologia.puce.edu.ec/imagesFTP/3415.2005NuestraCiencia7.pdf

86) A peptidomics study reveals the impressive antimicrobial peptide arsenal of the wax moth Galleria mellonella.
Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD.
Insect Biochem Mol Biol. 2009 Nov;39(11):792-800. Epub 2009 Sep 26.
PMID: 19786100

No comments: